Endocrine Abstracts

Introduction: Hyperprolactinemia (HP) is a common disorder in endocrinology. Based on the various etiology, HP could be divided into: physiological, pathological, drug-induced and idiopathic HP. Regardless of its origin, HP usually affects reproductive endocrine axis. The aim of the study was to determine differences in menstrual cycle abnormalities in patients with different causes of hyperprolactinemia.Patients and methods: The study included 81 patien...

Introduction: Physiological changes of pregnancy could be similar with classical presentation and biological confirmation of Cushing’s Syndrome (CS). To diagnose CS in pregnancy is very difficult especially in previously healthy women. Since the hypercortisolemia in the pregnancy increase maternal and foetal morbidity it is a concern for endocrinologists, gynaecologists, and paediatricians.Patient case report: Herein, we present young woman (23 year...

Introduction: Adrenal incidentalomas are defined as adrenal lesions incidentally discovered during radiological imaging of the abdomen without prior suspicion of adrenal disease. Approximately 70% of adrenal incidentalomas are non-functional adenomas. Pheochromocytoma presents only 5–7% of the remaining functional incidentalomas. Asymptomatic pheochromocytoma-incidentaloma is usually smaller than 1 cm. Large pheochromocytoma, incidentally found, without any clinical signs...

Introduction: The aim of this study was to compare prolactin receptor gene (Prlr) expression in the duodenum, vertebra and kidney, during physiological and medicamentous hyperprolactinaemia.Methods: Wistar female rats 18 weeks old were divided into: Group P: nine rats, 3 week pregnant; Group M: ten rats that were intramuscular administrated Sulpirid (10 mg/kg) twice daily for 3 weeks; and age matched nulliparous rats as a control group: ten rats...

Background/aim: This study was conducted to determine hyperprolactinemia significance in starting and maintaining sterile inflammation in breast tissue.Methods: We observed 50 patients with nipple discharge syndrome. Patients were divided into clinical group (27 patients with hyperprolactinemia and nipple discharge) and first control group (23 patients with normal serum prolactin and nipple discharge). The second control group included patients from clin...

Objectives: There are reports which suggests that TSH levels are independetly associated with components of metabolic syndrome. The aim of this study was to investigate the relatinship between thyroid stimulating hormone (TSH) and metabolic syndrome (MetS) in owerweight and obese euthyroid subjects.Methods: In 80 euthyroid owerweight and obese subjects, 44 women and 36 man, fasting blood semples were analyzed for glucose, triglycerides and HDL and estima...

Introduction: Adrenal incidentalomas (AI) are tumours revealed during radiological procedures in patients without previous suspicion for adrenal disease. This study was conducted to determine the frequency of functional AI.Patients and methods: Thirty-eight patients with AI were included in the study. The following parameters were considered: patient age, gender, size and location of the tumour, and radiological characteristics of adrenal masses. In orde...

Introduction: During pregnancy (state with physiological hyperprolactinemia-HP) mothers require larger calcium amount for fetal growth. It has been shown that PRL stimulate intestinal calcium absorption in physiological HP, which can protect mother’s skeletal system from further mineral density loss. On the other hand, medicamentous-related hyperprolactinemia is more frequently associated with reduced BMD and increased fracture risk. We conducted the experimental study to...